Author | Number of patients | Age in years (n) | Laterality (n) | Location (n) | Treatment modality (n) | Recurrence (n) | Follow up (months) | Response (n) |
---|---|---|---|---|---|---|---|---|
Parikh et al. (2018) [29] | 1 | 66 | Bilateral | Bulbar conjunctiva | Topical cyclosporine 0.05% | None | 3 | Partial |
Moraes et al. (2017) [14] | 1 | 40 | Unilateral | Bulbar conjunctiva | Topical corticosteroids | None | 36 | Complete |
Shields et al. (2017) [8] Shields et al. (2004) [9] Shields et al. (2001)a [1] | 113 | Mean: 43.2 Range: 5.3–86.3 age 0–30, (41) age 31–60, (30) age > 60, (36) | N/A | Fornix (34), Tarsal conjunctiva (6), Plica (15), Caruncle (8), Diffuse (1), Limbal bulbar conjunctiva (13), Extralimbal bulbar conjunctiva (30) | Topical corticosteroids (18), Excision (67), External Beam Radiotherapy (7), Observation (21) | Systemic lymphoma (1) | N/A – survey over 40 years | N/A |
Nivean et al. (2017) [19] | 1 | 17 | Unilateral | Nasal conjunctiva | Excision followed by oral corticosteroids | None | 24 | Partial |
AlAkeely et al. (2017) [6] | 24 | Mean: 11.6 Range: 7–17 | Unilateral(15) Bilateral (9) | Bulbar conjunctiva, nasally (23) and laterally (1) | Primary excision (17), Topical corticosteroids (4) or topical antihistamines (2) or topical antibiotic (1) followed by excision | 1 patient at 1 yr. & 1 patient at 2 yrs. postoperatively, both post-excision | Mean: 49 Range: 12–98 | Complete (17), Partial (7) |
Vaivanijkul et al. (2017) [37] | 1 | 5 | Unilateral | Bulbar conjunctiva | Incisional biopsy & Observation (EBV-related lesion) | None | 2 | Complete |
Brazert et al. (2015) [18] | 1 | 14 | Unilateral | Bulbar conjunctiva | Oral methylprednisolone | None | 32 | Complete |
Beykin et al. (2014) [28] | 7 | Mean: 13.6 Range: 6–21.5 | Unilateral (6) Bilateral (1) | Plica semilunaris/caruncle | Excision | None | Mean: 72 Range: 20–168 | Complete |
Koay et al. (2012) [26] | 1 | 50 | Bilateral | Bulbar conjunctiva/Cornea | Excision | None | 12 | N/A |
Herwig et al. (2012) [10] | 7 | Median: 23 Range: 8–77 | Unilateral (4) Bilateral (2)b | Caruncle (2), Plica (1), Inferior fornix (1), Nasal conjunctiva adjacent to plica (3) | Excision | None | Range: 12–132 | N/A |
Al-Mujaini et al. (2012) [27] | 2 | 9 and 14 | Unilateral | Nasal conjunctiva close to plica & medial canthus, respectively | Excision | None | Range: 9–10 | Complete |
Fukuhara et al. (2012)c [12] | 1 | 35 | Bilateral | Upper and lower conjunctival fornix | Observation | Conjunctival lymphoma | 11 | N/A |
Ahmed et al. (2011) [16] | 1 | 70 | Unilateral | Superomedial conjunctival quadrant | Intralesional steroids (triamcinolone acetonide) | None | N/A | Complete |
Lam et al. (2011) [25] | 1 | 13 | Bilateral | Bilateral nasal bulbar conjunctiva adjacent to plica | Excision | None | 6 | Partial |
Oh DH et al. (2011) [31] | 1 | 27 | Bilateral | Nasal conjunctiva | Anti-VEGF subconjunctival injection (Bevacizumab) | None | 12 | Complete |
Stacy et al. (2010) [4] | 6 | Median: 40 Range:8–77 | Unilateral (5) Bilateral (1) | Inferior formix (1), Inferolateral bulbar conj (1), Superonasal bulbar conj (1), Bilateral medial bulbar conj (1), Plica/caruncular complex (2) | Excision | None | Range: 1–36 | N/A |
Bagheri et al. (2007) [7] | 5 | Mean: 14 Range: 6–18 | Unilateral (5) | Caruncle lesions (3), plica semilunaris (2) | Excision | None | Mean: 45.8 Range: 2–108 | Complete |
Finger et al. (2007) [30] | 1 | 33 | Bilateral | Superior tarsal conjunctiva and inferior fornix | Topical Interferon 1 MIU/mL | None | 6 | Partial |
Reddy et al. (2006) [20] | 1 | 31 | Unilateral | Plica and caruncle | Excision | None | 24 | Complete |
Ioannidis et al. (2005) [15] | 1 | 59 | Bilateral | Superotemporal conjunctiva | Topical dexamethasone (Maxitrol) | None | N/A | Partial |
Telander et al. (2005) [17] | 1 | 72 | Unilateral | Nasal conjunctiva | Subconjunctival steroid injection (triamcinolone acetonide) | None | 9 | Complete |
Rofail et al. (2005) [23] | 1 | 73 | Unilateral | Superotemporal conjunctiva | Excision | None | 1 | N/A |
Kim et al. (2005) [24] | 1 | 14 | Bilateral | Bulbar conjunctiva, near the medial canthus | Excision | None | 24 | Complete |
Tang et al. (2003) [32] | 1 | 13 | Unilateral | Caruncle, plica, and superomedial bulbar conjunctiva | Incisional biopsy & Observation (spontaneous resolution along with patient’s EBV-negative tonsillar enlargement) | None | 24 | Complete |
Mannami et al. (2001) [33] | 1 | 78 | Unilateral | N/A | Observation | N/A | Lost to follow up | N/A |
Hundsdoerfer et al. (2000) [22] | 1 | 12 | Unilateral | Nasal conjunctiva | Incisional biopsy & Observation (EBV-related lesion) | None | 8 | Complete |
Feinberg et al. (2000) [38] | 2 | 19 and 8 | Bilateral and Unilateral | Medial canthus/caruncle/plica & Inferior conjunctiva, involving the fornix and extending into the caruncle, respectively | Incisional biopsy & Observation (19 yo patient), Excision (8 yo patient) – Both patients had EBV-related lesions | None | 24 | Complete |
McLeod et al. (1999) [5] | 2 | 12 and 7 | Unilateral | Nasal bulbar conjunctiva with involvement of the adjacent semilunar fold & Left caruncle, inferior fornix, respectively | Excision (both patients) followed by oral corticosteroids (7 yo patient) | None | 12 and 42 | Partial |
Coupland et al. (1998) [2] | 3 | 14, 32 and 35 | N/A | Conjunctiva | Topical corticosteroids | 1 patient after 5 years | Median: 31.3 Range:6.4–125.5 | Partial |
Urbak et al. (1993) [36] | 1 | 14 | Unilateral | Nasal bulbar conjunctiva | Observation (EBV-related lesion) | None | 2 | Complete |
Gardner et al. (1991) [34] | 1 | 38 | Unilateral | Superonasal conjunctiva | Observation (EBV-related lesion) | None | 12 | Complete |
Knowles et al. (1990) [21] | 9 | Median: 61 Range: 17–93 | N/A | N/A | Excision | N/A | N/A | N/A |
Meisler et al. (1981) [35] | 1 | 11 | Unilateral | Upper tarsal conjunctiva | Observation (EBV-related lesion) | None | 1 | Complete |
Sigelman et al. (1978) [11] | 33 | Median: 55 Range: 9–78 | Unilateral (26) Bilateral (7) | Inferior fornix (15), Bulbar conjunctiva (12), Plica/caruncle (4) | Excision (13), Excision & Corticosteroids (1), Excision & External Beam Radiotherapy (13), External Beam Radiotherapy (4), Observation (2) | 7 patients (excision: 3, excision & corticosteroids:1, excision & irradiation: 2, irradiation: 1) | 72 | Complete |