From: Classification, diagnosis, and management of conjunctival lymphoma
Therapy type | Author | Year of publication | Number of eyes | Laterality | Histologic subtype or tumor grade | Response rate (CR + PR) | Follow up (months) | Local recurrence rate | Side effects |
---|---|---|---|---|---|---|---|---|---|
Radiotherapy | Baldini et al. [53] | 1998 | 5 | Unilateral | EMZL (100%) | 100% | 76 (median) | 0% | Cataract (1 patient) |
Bhatia et al. [54] | 2002 | 17 | Unspecified | Unspecified | 100% | Unspecified | Unspecified | Cataract, dry eye, corneal toxicity (unspecified) | |
Bolek et al. [55] | 1999 | 4 | Unilateral | Low-grade (100%) | 100% | 12.6 (median) | 0% | Ocular irritation, conjunctivitis, cataract (unspecified) | |
Dunbar et al. [56] | 1990 | 10 | 8 unilateral; 1 bilateral | Unspecified | 100% | 29.5 (median) | 0% | Epilation of eyelashes, erythema of the eyelid, conjunctival injection; excessive tearing (25%) | |
Erickson et al. [57] | 1992 | 15 | 7 unilateral; 4 bilateral | EMZL (100%) | 93% | Unspecified | Unspecified | Â | |
Hasegawa et al. [58] | 2003 | 9 | Unilateral | EMZL (67%); DLBCL (11%); unspecified (22%) | 100% | 94 (median) | 0% | Cataract (55.6%) | |
Jereb et al. [31] | 1984 | 5 | Unilateral | DWDL (60%); NWDL (20%); DPDL (20%) | 100% | 22 (median) | 0% | Slight erythema and conjunctivitis in 1 patient | |
Kennerdell et al. [59] | 1999 | 4 | Unspecified | EMZL (100%) | 100% | Â | Unspecified | Mild xerophthalmia and chemosis (unspecified) | |
Kuhnt et al. [24] | 2003 | 1 | Unilateral | EMZL | 100% | 144 | 0% | Cataract | |
Lee, G-I et al. [60] | 2018 | 121 | 37 unilateral; 42 bilateral | EMZL (100%) | 100% | 61.3 (median) | 98% | Dry eye (26.6%); eye pain (5.1%); tearing (6.3%); cataract (6.3%) | |
Lee, S-w et al. [23] | 2002 | 4 | Unspecified | EMZL (100%) | 100% | 31 (median) | 0% | Conjunctivitis (100%) | |
Liao et al. [61] | 2002 | 12 | Unspecified | Low-grade (83%), Intermediate-grade (17%) | 100% | 56.4 (mean) | 0% | Lacrimal gland dysfunction (50%); cataract (25%) | |
Martinet et al. [62] | 2003 | 34 | 22 unilateral; 6 bilateral | Low-grade (100%) | 100% | 55 (median) | 0% | Inflammatory reaction; cataract (unspecified) | |
Matsuo et al. [63] | 2004 | 6 | 4 unilateral; 2 bilateral | EMZL (100%) | 100% | 48 (median) | 0% | Unspecified | |
Pelloski et al. [64] | 2001 | 11 | 9 unilateral; 2 bilateral | SLL (91%); SLP (9%) | 100% | 87.5 (median) | 0% | Cataract (18%); diabetic retinopathy (9%); epiphora (9%) | |
Shirota et al. [65] | 2017 | 19 | Unspecified | Unspecified | 100% | 32 (median) | 0% | Cataract (unspecified) | |
Smitt & Donaldson [13] | 1993 | 20 | 10 unilateral; 5 bilateral | DSC (45%); DWDL (25%); FM (20%); F + DSC (5%); ALH (5%) | Unspecified | 44 (median) | 6.7% | Mild conjunctival irritation (unspecified) | |
Stafford et al. [66] | 2001 | 16 | Unspecified | Unspecified | Unspecified | 64.2 (median) | 6.25% | Â | |
Uno et al. [67] | 2003 | 29 | Unspecified | EMZL (100%) | 100% | 46 (median) | 10% | Cataract, conjunctival irritation (unspecified) | |
Vitu et al. [68] | 1991 | 19 | 9 unilateral; 5 bilateral | Unspecified | 100% | Unspecified | 7% (bilateral recurrence in patient with bilateral disease) | Cataract (31.6%) | |
Xicoy et al. [69] | 2002 | 5 | 3 unilateral; 1 bilateral | EMZL (100%) | 100% | 50.5 (median) | 0% | Conjunctivitis and epiphora (50%) | |
IFN-alpha | Blasi et al. [70] | 2012 | 20 | 12 unilateral; 4 bilateral | EMZL (100%) | 100% | 65 (median) | 15% | Temporary conjunctival chemosis and other ocular discomfort associated with injection; transient flu-like syndrome (100%) |
Cellini et al. [71] | 1996 | 1 | Unilateral | EMZL | 100% | 12 | 0% | Â | |
Holds et al. [72] | 2012 | 2 | Bilateral | EMZL (100%) | 100% | 27 | 0% | Mild discomfort associated with injections, transient loss of appetite | |
Lachapelle et al. [73] | 2000 | 1 | Unilateral | EMZL | 100% | 6 | 0% | Transient headaches and nausea; subconjunctival hemorrhage | |
Lucas et al. [74] | 2003 | 2 | Bilateral | Likely EMZL | 100% | 18 | 0% | Â | |
Ross et al. [75] | 2004 | 2 | Bilateral | Unspecified | 100% | 12 | 0% | Injection discomfort, mild flu-like illness | |
Zayed et al. [76] | 2013 | 1 | Unilateral | EMZL | 100% | 10 | 0% | Â | |
Zinzani et al. [77] | 1997 | 4 | Unilateral | EMZL (100%) | 100% | 32 (median) | 0% | Â | |
Zinzani et al. [78] | 1999 | 4 | Unspecified | EMZL (100%) | 100% | 47 (median) | 0% | Â | |
Rituximab | Crespo et al. [79] | 2014 | 2 | Bilateral | EMZL | 100% | 9 | 0% | Dry eye |
Ferreri et al. [80] | 2011 | 3 | 1 unilateral; 2 bilateral | EMZL (100%) | 100% | 11.5 (median) | 0% | Ocular discomfort associated with injection (1 patient) | |
Rodriguez Villa et al. [81] | 2017 | 1 | Unilateral | FL | 100% | 10 | 0% | Â | |
Antibiotic therapy | Abramson, Rollins, and Coleman [82] (PrevPak or Doxycycline) | 2005 | 3 | Unilateral | EMZL or unspecified low-grade (100%) | 100% | 21 (median) | 0% | Â |
Danilko et al. [83] (Clarithromycin) | 2013 | 1 | Unilateral | EMZL | 100% | 0 | 0% | Â | |
Ferreri et al. [84] (Doxycycline) | 2006 | 14 | Unspecified | EMZL (100%) | 42.8% | Unspecified | 21.4% | Â | |
Govi et al. [85] (Clarithromycin) | 2010 | 5 | 3 unilateral; 1 bilateral | EMZL (100%) | 100% | 27 (median) | 0% | Unspecified | |
Grünberger et al. [86] (Doxycycline) | 2006 | 5 | 1 unilateral; 2 bilateral | EMZL (100%) | 0% | 9 (median) | N/A |  | |
Höh et al. [87] (Doxycycline) | 2016 | 1 | Unilateral | EMZL | 100% | 60 | 0% |  |