Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis

Table 1 Demographics and characteristics of the study cohorts

		Controls	All MS	MSNON	MSON	P value
		(40, eyes)^a	(38, eyes)	(25, eyes)	(13, eyes)	(All MS vs. HC)	(MSNON vs. HC)	(MSON vs. HC)	(MSON vs. MSNON)
Age, yr.; mean (SD)		29.8 (10.3)	36.4 (10.4)	36.9 (11.2)	35.6 (9.1)	0.002 ^b	0.009 ^b	0.013 ^b	0.7^b
Sex; Female n (%)		14 (70%)	27 (71%)	18 (72%)	9 (69%)	0.92^c	0.86^c	0.96^c	0.86^c
Disease Duration, yr.; median (Q1–3)		–	7 (3,15)	6 (3,13)	8 (4,15)	–	–	–	0.44^b
Race; Caucasian n (%)		11 (55%)	23 (65%)	15 (60%)	8 (62%)	0.13^c	0.27^c	0.54^c	1.00^c
Contrast Letter Acuity; mean (SD)	100%	–	55.9 (11.1)	57.0 (10.3)	54.0 (12.7)	–	–	–	0.63^b
	2.5%	–	26.6 (13.7)	26.6 (13.9)	26.5 (13.8)	–	–	–	0.87^b
	1.25%	–	12.2 (11.5)	13.5 (12.2)	9.8 (10.2)	–	–	–	0.34^b

HCs = healthy controls; MS = multiple sclerosis; MSNON = MS without optic neuritis; MSON = MS with optic neuritis; yr = year; SD = standard deviation; Q1 = first quartile; Q3 = third quartile
^aboth eyes of HCs were included in the study (HC subjects, n = 20) while only one eye of each patient with MS was included (MS patients, n = MS eyes)
^bWilcoxon rank-sum test
^cChi-squared test
P ≤ 0.05 indicates significance

ISSN: 2326-0254