Fig. 2
From: Evaluation of markers of outcome in real-world treatment of diabetic macular edema
Examples of the difficulties in rating the ellipsoid zone (EZ) at baseline and after the 3-monthly injection of anti-VEGF. a. A small subfoveal neuroretinal detachment and in the shadowing cone effect of a retinal cyst makes the rating of the EZ difficult. In this case the EZ was rated as ‘disrupted’ by consensus. b. The EZ seems to be disrupted with an intact external limiting membrane (ELM). c and d Eyes shown in (a) and (b) after the loading dose. The EZ is now clearly visible, rated as ‘intact’ by both graders. e. EZ after the loading dose being rated as ‘disrupted’