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Table 3 Changes in BSCVA and Kmax between Treatment Groups vs. Fellow Eye Controls

From: Corneal collagen crosslinking in patients treated with dextran versus isotonic hydroxypropyl methylcellulose (HPMC) riboflavin solution: a retrospective analysis

HPMC Treatment Eye Control Eye   
Mean Change in BSCVA (SD) Mean Mean n value** p-value
1 Month 0.18 (0.17) 0.01 (0.06) 12 < 0.05
 6 Months − 0.02 (0.16) − 0.04 (0.09) 14 0.72
 12 Months − 0.05 (0.15) − 0.02 (0.08) 14 0.65
 24 Months − 0.03 (0.13) − 0.03 (0.08) 8 0.99
Mean Change in Kmax (SD)
 1 Month 4.9 (5.89) −0.40 (2.93) 6 0.08
 6 Months −0.27 (2.13) 0.81 (1.14) 9 0.13
12 Months −0.88 (2.18) 1.13 (1.74) 9 < 0.05
Dextran Treatment Eye Control Eye   
Mean Change in BSCVA (SD) Mean Mean n value p-value
 1 Month −0.03 (0.20) − 0.02 (0.11) 26 0.74
6 Months −0.13 (0.18) 0.00 (0.08) 22 < 0.01
12 Months −0.16 (0.22) 0.00 (0.10) 19 < 0.01
24 Months −0.19 (0.17) 0.00 (0.08) 10 < 0.01
Mean Change in Kmax (SD)
 1 Month 0.34 (1.88) 0.39 (0.81) 16 0.95
 6 Months − 1.25 (3.67) 0.24 (0.96) 16 0.17
 12 Months −2.19 (6.84) −0.42 (1.09) 13 0.38
  1. bolded values represent statistical significance
  2. **number of patients is less than Table 2 due to incomplete data availability
  3. BSCVA= best spectacle corrected visual acuity, HPMC= hydroxypropyl methylcellulose, SD= standard deviation