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Table 1 Summary of significant optical coherence tomography angiography findings in neurological disorders *

From: Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research

Author Parameter Disorder N (eyes) Measurement Compare N (eyes) Measurement % Difference
Wang et al. (2014) [25] flow index - ONH MSON 14 0.140 ± 0.020 HC 21 0.160 ± 0.010 −14.3%
Spain et al. (2017) [28] flow index - ONH MSON 25 N/A HC 55 N/A −14.7%
Feucht et al. (2017) [26] vessel density % - SVP MSON 16 50 HC 100 54 −4.0%
  vessel density % - SVP MSON 16 50 MSNON 56 53 −3.0%
  vessel density % - DVP MSON 16 62 HC 100 64 −2.0%
  vessel density % - DVP MSON 16 62 MSNON 56 64 −2.0%
Lanzillo et al. (2017) [27] vessel density % - parafovea IS MSON 23 50.96 ± 5.33 MSNON 77 51.71 ± 5.82 −1.5%
  vessel density % - macula MS 100 48.71 ± 4.44 HC 92 53.08 ± 3.31 −9.0%
Bulut et al. (2017) [29] area (mm 2 ) - FAZ AD 26 0.47 ± 0.18 HC 26 0.33 ± 0.08 29.8%
  vessel density % - macula AD 26 45.50 ± 3.85 HC 26 48.67 ± 3.29 −7.0%
Jiang et al. (2017) [31] vessel density - SVP AD 12 1.68 HC 21 1.74 −3.6%
  vessel density - DVP AD 12 1.65 HC 21 1.72 −4.2%
  vessel density - DVP SN MCI 19 1.54 HC 21 1.62 −5.2%
Fard et al. (2018) [33] vessel density % - PC NAION 31 30.1 ± 6 HC 77 42.3 ± 2.3 −40.5%
Song et al. (2017) [36] vessel density % - PC NAION 41 52.07 ± 7.68 HC 30 58.68 ± 3.16 −12.7%
Ling et al. (2017) [35] nonperfusion area % - ONH NAION 21 17.84 ± 6.18 HC 19 8.61 ± 1.65 51.7%
  1. Abbreviations: ONH = optic nerve head; SVP = superficial vascular plexus; DVP = deep vascular plexus; IS = inferior sector; FAZ = foveal avascular zone; SN = superior nasal quadrant; PC = peripapillary capillaries; MSON = Disorder: multiple sclerosis with a history of optic neuritis; MS = multiple sclerosis with and without history of optic neuritis; AD = Alzheimer’s disease; MCI = mild cognitive impairment; NAION = non-arteritic anterior ischemic optic neuropathy; HC = Compare: healthy controls; MSNON = multiple sclerosis without a history of optic neuritis
  2. *Listed comparisons were significantly different (P < 0.05)