Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research

Table 1 Summary of significant optical coherence tomography angiography findings in neurological disorders *

Author	Parameter	Disorder	N (eyes)	Measurement	Compare	N (eyes)	Measurement	% Difference
Wang et al. (2014) [25]	flow index - ONH	MSON	14	0.140 ± 0.020	HC	21	0.160 ± 0.010	−14.3%
Spain et al. (2017) [28]	flow index - ONH	MSON	25	N/A	HC	55	N/A	−14.7%
Feucht et al. (2017) [26]	vessel density % - SVP	MSON	16	50	HC	100	54	−4.0%
	vessel density % - SVP	MSON	16	50	MSNON	56	53	−3.0%
	vessel density % - DVP	MSON	16	62	HC	100	64	−2.0%
	vessel density % - DVP	MSON	16	62	MSNON	56	64	−2.0%
Lanzillo et al. (2017) [27]	vessel density % - parafovea IS	MSON	23	50.96 ± 5.33	MSNON	77	51.71 ± 5.82	−1.5%
	vessel density % - macula	MS	100	48.71 ± 4.44	HC	92	53.08 ± 3.31	−9.0%
Bulut et al. (2017) [29]	area (mm ² ) - FAZ	AD	26	0.47 ± 0.18	HC	26	0.33 ± 0.08	29.8%
	vessel density % - macula	AD	26	45.50 ± 3.85	HC	26	48.67 ± 3.29	−7.0%
Jiang et al. (2017) [31]	vessel density - SVP	AD	12	1.68	HC	21	1.74	−3.6%
	vessel density - DVP	AD	12	1.65	HC	21	1.72	−4.2%
	vessel density - DVP SN	MCI	19	1.54	HC	21	1.62	−5.2%
Fard et al. (2018) [33]	vessel density % - PC	NAION	31	30.1 ± 6	HC	77	42.3 ± 2.3	−40.5%
Song et al. (2017) [36]	vessel density % - PC	NAION	41	52.07 ± 7.68	HC	30	58.68 ± 3.16	−12.7%
Ling et al. (2017) [35]	nonperfusion area % - ONH	NAION	21	17.84 ± 6.18	HC	19	8.61 ± 1.65	51.7%

Abbreviations: ONH = optic nerve head; SVP = superficial vascular plexus; DVP = deep vascular plexus; IS = inferior sector; FAZ = foveal avascular zone; SN = superior nasal quadrant; PC = peripapillary capillaries; MSON = Disorder: multiple sclerosis with a history of optic neuritis; MS = multiple sclerosis with and without history of optic neuritis; AD = Alzheimer’s disease; MCI = mild cognitive impairment; NAION = non-arteritic anterior ischemic optic neuropathy; HC = Compare: healthy controls; MSNON = multiple sclerosis without a history of optic neuritis
*Listed comparisons were significantly different (P < 0.05)

ISSN: 2326-0254