Skip to main content

Table 1 Mean change in near visual acuity (NVA) (Jaeger) and pupil size (PS) (mm) over time for the same presbyopic subjects receiving combined versus separate 3% carbachol plus 0.2% brimonidine, 0.2% brimonidine alone and 3% carbachol alone

From: Clinical outcomes of combined versus separate carbachol and brimonidine drops in correcting presbyopia

Time Combined drops Separate drops 3% Carbachol alone 0.2% Brimonidine alone P-Value*
Combined vs. separate Combined vs. 3% carbachol Combined vs. 2% brimonidine
Pre-treatment NVA (J) 8.6 ± 1.5 8.6 ± 1.5 8.6 ± 1.5 8.6 ± 1.5 1 1 1
PS (mm) 4.3 ± 0.5 4.3 ± 0.5 4.3 ± 0.5 4.3 ± 0.5 1 1 1
1-h NVA (J) 1.1 ± 0.3 3.4 ± 1 5.5 ± 1 7.7 ± 1.3 P < 0.0001 P < 0.0001 P < 0.0001
PS (mm) 1.2 ± 0.3 1.9 ± 0.3 2.8 ± 0.3 3.95 ± 0.5 P = 0.0006 P < 0.0001 P < 0.0001
2-h NVA (J) 1.1 ± 0.3 3.6 ± 1 5.9 ± 0.8 8.2 ± 1.3 P < 0.0001 P < 0.0001 P < 0.0001
PS (mm) 1.2 ± 0.3 2.2 ± 0.2 3 ± 0.3 4.2 ± 0.4 P < 0.0001 P < 0.0001 P < 0.0001
4-h NVA (J) 1.8 ± 0.4 4.5 ± 1 7 ± 1.2 8.5 ± 1.4 P < 0.0001 P < 0.0001 P < 0.0001
PS (mm) 1.7 ± 0.2 2.5 ± 0.3 3.5 ± 0.3 4.3 ± 0.5 P < 0.0001 P < 0.0001 P < 0.0001
8-h NVA (J) 2.3 ± 0.5 5.2 ± 0.8 7.5 ± 1 8.6 ± 1.5 P < 0.0001 P < 0.0001 P < 0.0001
PS (mm) 2.1 ± 0.3 2.8 ± 0.2 4 ± 0.3 4.3 ± 0.5 P = 0.0006 P < 0.0001 P < 0.0001
  1. NVA = near visual acuity; PS = pupil size
  2. *Level of statistical significance: P < 0.05