Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors

Table 2 Lipoprotein genes associated with AMD incidence and prevalence

Gene	Gene product	Chromosome	Function	Animal model	Association with AMD
ABCA1	ATP binding cassette subfamily A member 1	9q31.1	Cholesterol transport	KO [93, 225], conditional KO [94], transgenic [95]	Zareparsi et al. 2005 [69]
ABCA7	ATP binding cassette subfamily A member 7	19p13.3	Lipid homeostasis	KO [96]	Logue et al. 2014 [48]
APOE	Apolipoprotein E	19q13.2	Lipid catabolism	transgenic [97], KO [98]	Klaver et al. 1998 [67]
CETP	Cholesteryl ester transfer protein	16q21	Lipid metabolism	transgenic [99]	Chen et al. 2010 [50]
LIPC	Hepatic triglyceride lipase	15q21.3	Lipid metabolism	KO [100]	Chen et al. 2010 [50]
MMP9	Matrix metalloproteinase-9	20q13.12	ECM breakdown/angiogenesis	KO [101]	Hussain et al. 2011 [70]
PLTP	Phospholipid transfer protein	20q13.12	Lipid transfer to HDL	transgenic [102], KO [103]	Fritsche et al. 2015 [24]
VTN	Vitronectin	17q11	Cell adhesion/complement pathway	No	Fritsche et al. 2015 [24]

ISSN: 2326-0254