Table 1 Summarized list of biomarkers in keratoconus
Biomarker | Expression | Tissue/Cells | Technique/Method | Ref |
|---|---|---|---|---|
LOX | ↓ | Patient Corneal epithelium | RT-PCR | 47 |
COLIA1 | ↓ | |||
COLIVA1 | ↓ | |||
MMP9 | ↑ | Patient Corneal epithelium | RT-PCR | 48 |
TNFα | ↑ | |||
IL-6 | ↑ | |||
SMAD6 | ↓ | HKCs | RT-PCR/WB | 50 |
SMAD7 | ↓ | |||
ADH1B | ↓ | Cornea | Microarray/WB | 51 |
GSN | ↑ | Patient corneal epithelium | 2D-GE | 53 |
ENOA | ↑ | |||
S100A4 | ↑ | |||
KRT3 | ↑ |