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Table 1 Safety of CXL in thin corneas

From: Corneal collagen cross-linking (CXL) in thin corneas

Author, year No. of eyes Surgical procedures Follow up (months) VA and topography changes Endothelial loss Other complications
Kymionis, et al. 2012 [38] 14 Conventional 12 UDVA and CDVA improved, Kmean reduced Yes No
Hafezi, et al. 2009 [30] 20 Hypoosmolar riboflavin solution 6 Kmax stable or reduced No
Raiskup and Spoerl 2011 [42] 32 Hypoosmolar riboflavin solution 12 CDVA and Kmax stable No
Wu, et al. 2014 [43] 15 Hypoosmolar riboflavin solution 12 1 eye lost 1 line CDVA, the rest remained stable or improved, Kmax and Kmin reduced No No
Soeters and Tahzib 2015 [48] 13 Hypoosmolar riboflavin solution 12 CDVA improved, Kmax, Kmin and Kmean remain stable No No
Gu, et al. 2015 [45] 8 Hypoosmolar riboflavin solution 3 CDVA stable, Kmax stable Yes No
Filippello, et al. 2012 [28] 20 Transepithelial CXL 18 UDVA and CDVA improved, keratometry values decreased No No
Spadea and Mencucci 2012 [31] 16 Transepithelial CXL 6–12 UDVA and CDVA improved, Kmax reduced No No
Kymionis, et al. 2009 [29] 2 Custom epithelial debridement 9 Topography stable No No
Kaya, et al. 2011 [69] 2 Custom epithelial debridement 1 No
Mazzotta and Ramovecchi 2014 [70] 10 Custom epithelial debridement 12 UDVA, CDVA stable, Kmean reduced No No
Jacob, et al. 2014 [73] 14 Contact lens-assisted 6–7 CDVA stable, Kmax stable No No
  1. K max = Maximum keratometric reading, K min = Minimum keratometric reading, K mean = Mean keratometry reading, SimK = Simulated keratometry, VA = Visual acuity, UDVA = Uncorrected distance visual acuity, CDVA = Corrected distance visual acuity