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Table 1 TRP channel pharmacology and ocular cell type localization

From: Polymodal roles of transient receptor potential channels in the control of ocular function

TRP channel subtype Compound Concentration Role Expression/localization References
TRPC1 -TRPC3 2-APB 100 μM Antagonist HCEC Mouse retina TM [43,61,85]
TRPC4 2-APB 100 μM Antagonist RCECMouse retina [43,61,93]
TRPV1 Capsaicin 1 – 20 μM Agonist HCEC1, HCK HCEC-12 Rat retina HCjEC Rat and mouse retinas Human retina (tumour) Uvea (tumour) [3,41,46,49,59,60,66,71,94]
TRPV1 Capsazepine 1 – 10 μM Antagonist HCEC HCK HCEC-12 HCjEC [46,59,60,66,71]
TRPV2 2-APB 200 - 400 μM Agonist HCEC-12 HCEC [71,95]
TRPV2 Camphor 400 μM Agonist RPE [48]
TRPV3 2-APB 200 μM Agonist HCEC [95]
TRPV4 4α-PDD, 5 μM Agonist HCEC-12 HCEC2, HCjEC [46,63,70]
TRPV4 GSK 1016790A 5 μM Agonist HCEC-12 [70]
TRPM8 Menthol 50 - 500 μM Agonist HCNF HCEC-12 [54,55,57,72,96]
TRPM8 Icilin 2 – 60 μM Agonist HCK3, HCEC3 CEC-12 Human retina (tumour) Uvea (tumour) [46,49,72,75]
TRPM8 Eucalyptol 3000 μM Agonist HCEC-12 [72]
TRPM8 BCTC 10 μM Antagonist HCEC-12 [72]
TRPA1 Icilin 2 – 60 μM Agonist HCEC-12 TM [72,75,85]
  1. 1activation by hypertonic challenge.
  2. 2activation by hypotonic challenge.
  3. 3Mergler et al. (unpublished data).
  4. HCEC = human corneal epithelial cells.
  5. RCEC = rabbit corneal epithelial cells.
  6. HCjEC = human conjunctival epithelial cells.
  7. HCK = human corneal keratocytes (stroma).
  8. HCEC-12 = human corneal endothelial cells.
  9. HCNF = human corneal nerve fibres.
  10. RPE = retinal pigment epithelium.
  11. TM = Trabecular meshwork.