Polymodal roles of transient receptor potential channels in the control of ocular function

Table 1 TRP channel pharmacology and ocular cell type localization

TRP channel subtype	Compound	Concentration	Role	Expression/localization	References
TRPC1 -TRPC3	2-APB	100 μM	Antagonist	HCEC Mouse retina TM	[43,61,85]
TRPC4	2-APB	100 μM	Antagonist	RCECMouse retina	[43,61,93]
TRPV1	Capsaicin	1 – 20 μM	Agonist	HCEC¹, HCK HCEC-12 Rat retina HCjEC Rat and mouse retinas Human retina (tumour) Uvea (tumour)	[3,41,46,49,59,60,66,71,94]
TRPV1	Capsazepine	1 – 10 μM	Antagonist	HCEC HCK HCEC-12 HCjEC	[46,59,60,66,71]
TRPV2	2-APB	200 - 400 μM	Agonist	HCEC-12 HCEC	[71,95]
TRPV2	Camphor	400 μM	Agonist	RPE	[48]
TRPV3	2-APB	200 μM	Agonist	HCEC	[95]
TRPV4	4α-PDD,	5 μM	Agonist	HCEC-12 HCEC², HCjEC	[46,63,70]
TRPV4	GSK 1016790A	5 μM	Agonist	HCEC-12	[70]
TRPM8	Menthol	50 - 500 μM	Agonist	HCNF HCEC-12	[54,55,57,72,96]
TRPM8	Icilin	2 – 60 μM	Agonist	HCK^3, HCEC³ CEC-12 Human retina (tumour) Uvea (tumour)	[46,49,72,75]
TRPM8	Eucalyptol	3000 μM	Agonist	HCEC-12	[72]
TRPM8	BCTC	10 μM	Antagonist	HCEC-12	[72]
TRPA1	Icilin	2 – 60 μM	Agonist	HCEC-12 TM	[72,75,85]

ISSN: 2326-0254