From: Polymodal roles of transient receptor potential channels in the control of ocular function
TRP channel subtype | Compound | Concentration | Role | Expression/localization | References |
---|---|---|---|---|---|
TRPC1 -TRPC3 | 2-APB | 100 μM | Antagonist | HCEC Mouse retina TM | [43,61,85] |
TRPC4 | 2-APB | 100 μM | Antagonist | RCECMouse retina | [43,61,93] |
TRPV1 | Capsaicin | 1 – 20 μM | Agonist | HCEC1, HCK HCEC-12 Rat retina HCjEC Rat and mouse retinas Human retina (tumour) Uvea (tumour) | [3,41,46,49,59,60,66,71,94] |
TRPV1 | Capsazepine | 1 – 10 μM | Antagonist | HCEC HCK HCEC-12 HCjEC | [46,59,60,66,71] |
TRPV2 | 2-APB | 200 - 400 μM | Agonist | HCEC-12 HCEC | [71,95] |
TRPV2 | Camphor | 400 μM | Agonist | RPE | [48] |
TRPV3 | 2-APB | 200 μM | Agonist | HCEC | [95] |
TRPV4 | 4α-PDD, | 5 μM | Agonist | HCEC-12 HCEC2, HCjEC | [46,63,70] |
TRPV4 | GSK 1016790A | 5 μM | Agonist | HCEC-12 | [70] |
TRPM8 | Menthol | 50 - 500 μM | Agonist | HCNF HCEC-12 | [54,55,57,72,96] |
TRPM8 | Icilin | 2 – 60 μM | Agonist | HCK3, HCEC3 CEC-12 Human retina (tumour) Uvea (tumour) | [46,49,72,75] |
TRPM8 | Eucalyptol | 3000 μM | Agonist | HCEC-12 | [72] |
TRPM8 | BCTC | 10 μM | Antagonist | HCEC-12 | [72] |
TRPA1 | Icilin | 2 – 60 μM | Agonist | HCEC-12 TM | [72,75,85] |