Estimation of changes of RNFLT of clock hour 1, 2 and 10 average over time. The left column is before registration, right column is after registration. The dashed lines are the fits of individual primates. The individual fits display very similar trends as compared to the linear mixed effects model fits. The clock hour 1 and 2 averages decreased significantly before registration (p = 0.0058 for clock hour 1 and p = 0.0054 for clock hour 2), but stayed constant after registration. The clock hour 10 average RNFLT increased significantly before registration (p = 0.0298), but was constant after registration.