Effect of spectacle lenses with aspherical lenslets on choroidal thickness in myopic children: a 3-year follow-up study

Huang, Yingying; Li, Xue; Zhuo, Zuopao; Zhang, Jiali; Que, Tianxing; Yang, Adeline; Drobe, Björn; Chen, Hao; Bao, Jinhua

doi:10.1186/s40662-024-00383-4

Eye and Vision

Table 2 Choroidal thickness adjusted for age, sex, baseline axial length and refractive error in different regions

From: Effect of spectacle lenses with aspherical lenslets on choroidal thickness in myopic children: a 3-year follow-up study

Time	Group	SF	C	N3	T3	S3	I3	N6	T6	S6	I6
Baseline	HAL (μm)	236.83 ± 58.03	238.59 ± 57.16	213.64 ± 54.55	252.58 ± 56.47	249.32 ± 55.3	240.37 ± 55.97	170.91 ± 49.18	259.47 ± 52.82	253.47 ± 54.22	234.03 ± 52.58
	SAL-HAL (μm)	227.8 ± 57.71	230.72 ± 56.84	209.6 ± 54.24	245.33 ± 56.15	241.66 ± 54.98	238.96 ± 55.66	171.23 ± 48.9	255.65 ± 52.52	247.32 ± 53.92	241.26 ± 52.28
	SVL-HAL (μm)	215.96 ± 57.4	217.1 ± 56.54	195.81 ± 53.97	231.47 ± 55.86	225.12 ± 54.7	225.18 ± 55.37	159.04 ± 48.65	237.81 ± 52.25	230.83 ± 53.65	219.97 ± 52.01
	new-SVL (μm)	234.2 ± 58.04	233.22 ± 57.17	205.69 ± 54.56	250.6 ± 56.48	242.3 ± 55.31	237.17 ± 55.99	161.49 ± 49.19	258.4 ± 52.83	242.84 ± 54.23	227.4 ± 52.59
6 months	HAL (μm)	232.45 ± 62.94	240.65 ± 59.02	215.55 ± 56.84	255.14 ± 57.97	251.62 ± 57.66	242.76 ± 58.93	171.18 ± 51.8	261.9 ± 53.92	255.66 ± 56.88	234.88 ± 56.2
	SAL-HAL (μm)	221.96 ± 62.59	234.06 ± 58.69	212.45 ± 56.52	248.33 ± 57.65	246.35 ± 57.33	243.41 ± 58.61	171.49 ± 51.51	259.11 ± 53.62	250.65 ± 56.56	243.83 ± 55.88
	SVL-HAL (μm)	216.16 ± 62.26	222.3 ± 58.38	200.29 ± 56.23	237.49 ± 57.35	231.52 ± 57.04	230.55 ± 58.3	159.09 ± 51.24	247.63 ± 53.34	236.78 ± 56.27	225.49 ± 55.6
	new-SVL (μm)	222.4 ± 62.95	226.23 ± 59.04	199.77 ± 56.85	241.65 ± 57.98	237.24 ± 57.67	230.51 ± 58.95	156.14 ± 51.8	250.96 ± 53.93	240.03 ± 56.89	221.95 ± 56.21
12 months	HAL (μm)	231.74 ± 58.69	234.66 ± 58.51	211.85 ± 56.17	247.27 ± 56.37	245.97 ± 56.62	237.13 ± 58.22	170.71 ± 51.6	253.14 ± 51.65	251.22 ± 56.24	231.76 ± 55.41
	SAL-HAL (μm)	225.58 ± 58.36	229.19 ± 58.18	208.11 ± 55.86	241.98 ± 56.06	242.73 ± 56.3	240.05 ± 57.89	171.18 ± 51.31	252.42 ± 51.36	249.02 ± 55.93	242.57 ± 55.1
	SVL-HAL (μm)	215.84 ± 58.05	216.72 ± 57.88	195.5 ± 55.57	230.36 ± 55.77	226.68 ± 56	225.22 ± 57.59	157.91 ± 51.05	237.37 ± 51.09	234.01 ± 55.64	220.38 ± 54.81
	new-SVL (μm)	218.1 ± 58.7	217.11 ± 58.52	193.87 ± 56.18	232.22 ± 56.39	228.73 ± 56.62	222.88 ± 58.22	154.05 ± 51.62	240.44 ± 51.66	234.8 ± 56.25	215.77 ± 55.42
RM-MANOVA, P value	Time	0.661	0.372	0.525	0.551	0.515	0.431	0.942	0.396	0.468	0.937
	Group	0.550	0.433	0.429	0.465	0.305	0.573	0.378	0.414	0.321	0.192
	Time × group	0.100	0.006	0.025	0.001	0.005	0.003	0.175	< 0.001	0.086	0.009
RM-MANOVA in each group, P value	HAL	0.434	0.116	0.311	0.037	0.115	0.112	0.892	0.014	0.174	0.375
	SAL-HAL	0.384	0.173	0.187	0.066	0.210	0.211	0.964	0.051	0.455	0.583
	SVL-HAL	0.983	0.173	0.166	0.094	0.107	0.147	0.926	0.003	0.119	0.095
	new-SVL	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.001	< 0.001	0.005	< 0.001

HAL group, continued wearing HAL; SAL-HAL group, switched from wearing SAL to HAL; SVL-HAL group, switched from wearing SVL to HAL; new-SVL group, wore SVL for 1 year
P < 0.005 indicates statistical significance
HAL = spectacle lenses with highly aspherical lenslets; SAL = spectacle lenses with slightly aspherical lenslets; SVL = single vision spectacle lenses; SF = subfoveal choroidal thickness; C = 1 × 1 mm circular region; N3, S3, T3 and I3 = the nasal, superior, temporal and inferior regions measured at 1–3 mm; N6, S6, T6 and I6 = the nasal, superior, temporal and inferior regions measured at 3–6 mm; RM-MANOVA = repeated-measures multivariate analysis of variance

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