Corneal subbasal nerve plexus reinnervation and stromal cell morphology with different cap thicknesses in small incision lenticule extraction

Song, Yanzheng; Deng, Shijing; Lyv, Xiaotong; Xu, Yushan; Zhang, Fengju; Guo, Ning

doi:10.1186/s40662-024-00381-6

Eye and Vision

Table 3 Subbasal nerve plexus (SNP) measurement with different cap-thickness design at baseline and follow-ups

From: Corneal subbasal nerve plexus reinnervation and stromal cell morphology with different cap thicknesses in small incision lenticule extraction

Parameter	Time point
Parameter	Preop	1w postop	1m postop	3m postop	6m postop	P value
CNFD (no./mm²)
110 μm	16.943 ± 5.013	5.026 ± 3.967	7.537 ± 4.355	8.628 ± 4.810	8.471 ± 4.798	0.001*
120 μm	17.532 ± 6.689	7.634 ± 6.131	8.476 ± 5.985	9.492 ± 6.603	11.490 ± 6.884	0.026*
130 μm	18.882 ± 6.178	8.495 ± 5.969	7.599 ± 4.759	10.121 ± 7.206	12.328 ± 6.465	0.000*
P	0.467	0.017*	0.853	0.925	0.052
CNBD (no./mm²)
110 μm	16.548 ± 9.258	3.896 ± 4.733	6.040 ± 6.056	7.367 ± 5.547	10.943 ± 10.110	0.001*
120 μm	23.430 ± 15.620	7.354 ± 8.075	8.690 ± 8.500	11.968 ± 16.389	14.620 ± 13.283	0.009*
130 μm	27.637 ± 19.751	7.585 ± 7.102	8.180 ± 8.272	13.932 ± 12.643	18.836 ± 14.288	0.000*
P	0.061	0.095	0.593	0.391	0.107
CNFL (mm/mm²)
110 μm	13.078 ± 1.868	6.092 ± 1.881	7.109 ± 1.991	8.347 ± 2.726	8.460 ± 2.892	0.000*
120 μm	13.112 ± 3.030	7.720 ± 2.952	7.878 ± 3.406	8.604 ± 3.431	9.356 ± 3.364	0.016*
130 μm	13.904 ± 2.839	7.983 ± 2.538	8.405 ± 3.035	8.963 ± 3.296	10.534 ± 2.684	0.000*
P	0.244	0.012*	0.250	0.877	0.040*
CTBD (no./mm²)
110 μm	35.092 ± 12.384	12.409 ± 7.792	15.212 ± 8.670	18.829 ± 10.151	23.645 ± 14.870	0.002*
120 μm	41.209 ± 25.266	17.309 ± 12.706	21.045 ± 15.806	24.757 ± 23.124	26.657 ± 20.403	0.077
130 μm	50.008 ± 27.473	20.205 ± 10.081	21.459 ± 11.841	27.236 ± 18.805	35.159 ± 18.220	0.000*
P	0.071	0.014*	0.367	0.840	0.055
CNFA (mm/mm²)
110 μm	0.007 ± 0.001	0.004 ± 0.001	0.004 ± 0.001	0.004 ± 0.001	0.005 ± 0.002	0.000*
120 μm	0.007 ± 0.002	0.004 ± 0.001	0.004 ± 0.002	0.005 ± 0.002	0.005 ± 0.002	0.007*
130 μm	0.007 ± 0.002	0.004 ± 0.001	0.005 ± 0.001	0.005 ± 0.001	0.006 ± 0.002	0.000*
P	0.186	0.017*	0.097	0.668	0.292
CNFW (mm/mm²)
110 μm	0.021 ± 0.001	0.023 ± 0.002	0.022 ± 0.001	0.022 ± 0.002	0.022 ± 0.002	0.360
120 μm	0.021 ± 0.001	0.023 ± 0.003	0.022 ± 0.002	0.022 ± 0.001	0.022 ± 0.001	0.000*
130 μm	0.021 ± 0.001	0.023 ± 0.002	0.023 ± 0.002	0.022 ± 0.002	0.022 ± 0.001	0.032*
P	0.076	0.856	0.084	0.903	0.762
CNFrD (ratio scale)
110 μm	1.468 ± 0.017	1.366 ± 0.051	1.392 ± 0.042	1.406 ± 0.051	1.407 ± 0.049	0.000*
120 μm	1.465 ± 0.030	1.396 ± 0.053	1.393 ± 0.065	1.404 ± 0.051	1.412 ± 0.051	0.210
130 μm	1.476 ± 0.031	1.404 ± 0.044	1.414 ± 0.051	1.414 ± 0.043	1.438 ± 0.030	0.002*
P	0.260	0.010*	0.191	0.673	0.025*

CNFD = corneal nerve fiber density; CNBD = corneal nerve branch density; CNFL = corneal nerve fiber length; CTBD = corneal nerve fiber total branch density; CNFA = corneal nerve fiber area; CNFW = corneal nerve fiber width; CNFrD = corneal nerve fractal dimension
The P values in the right column show the statistical difference among different time points postoperatively, and the P values at the bottom row of each category represent the statistical difference among three groups
*Indicate statistical significance (P < 0.05)

Back to article page

ISSN: 2326-0254

Contact us

Submission enquiries: editorial@eandv.org
General enquiries: info@biomedcentral.com