Table 5 Summary of efficacy outcomes comparing Trab and EX over a follow-up duration of more than 1 year
Author (year) | Study design | Number of eyes Trab/EX | Primary surgical success definition | Secondary surgical success definition | Primary success rate at 1 year | Primary success rate at 2 years | Secondary success rate at 1 year | Secondary success rate at 2 years |
|---|---|---|---|---|---|---|---|---|
Gonzalez-Rodriguez (2016) [13] | RCT | 31/32 | 5 ≤ IOP ≤ 18 mmHg, a ≥ 20% reduction, no medications | 5 ≤ IOP ≤ 18 mmHg, a ≥ 20% reduction, with or without medications | NA | 42% vs. 43% (P = 0.78) | NA | 76% vs. 59% (P = 0.20) |
Netland (2014) [14] | RCT | 61/59 | 5 ≤ IOP ≤ 18 mmHg, with or without medications and without additional glaucoma surgeries | 5 ≤ IOP ≤ 15 mmHg, with or without medications and without additional glaucoma surgeries | 87% vs. 90% | 79% vs. 83% | 70% vs. 73% | 56% vs. 58% |
Dahan (2012) [15] | RCT | 15/15 | 5 < IOP < 18 mmHg, without medications | 5 < IOP < 18 mmHg, with or without medications | NA | NA | NA | NA |
de Jong L (2011) [16] | RCT | 39/39 | 4< IOP ≤ 18 mmHg, no medications | 4 < IOP ≤ 15 mmHg, no medications | 61.5% vs. 86.8% (P = 0.01) | 51.3% vs. 76.3% (P = 0.02) | 51.3% vs. 80.0% (P = 0.01) | 48.7% vs. 71.1% (P = 0.046) |
Wang (2017) [17] | Prosp | 24/24 | 5 ≤ IOP ≤ 21 mmHg, without surgical interventions | NA | 87.5% vs. 95.8% (P = 0.289) | NA | NA | NA |
Tojo (2018) [18] | Retro | 39/69 | IOP ≤ 15 mmHg or a ≥ 20% reduction, with or without medications | IOP ≤ 21 mmHg or a ≥ 20% reduction, with or without medications | NA | NA | NA | NA |
Liu (2015) [19] | Retro | 17/16 | 5 < IOP < 18 mmHg, no medications | 5 < IOP < 18 mmHg, with or without medications | 47% vs. 43% (P > 0.05) | NA | 76.5% vs. 75.0% (P > 0.05) | NA |
Moisseiev (2015) [20] | Retro | 61/39 | ≤ 20 mmHg or a ≥ 20% reduction, no medications | ≤ 20 mmHg or a ≥ 20% reduction, with or without medications | 62.3% vs. 66.6% | NA | 86.9% vs. 84.6% | NA |
Present study | Retro | 64/54 | 5 < IOP < 15 mmHg without medications and interventions | 5 < IOP < 18 mmHg without medications and interventions | 68% vs. 62% | 57% vs. 53% | 84% vs. 72% | 72% vs. 64% |