Gene | Gene product | Chromosome | Function | Animal model | Association with AMD |
---|---|---|---|---|---|
ABCA1 | ATP binding cassette subfamily A member 1 | 9q31.1 | Cholesterol transport | Zareparsi et al. 2005 [69] | |
ABCA7 | ATP binding cassette subfamily A member 7 | 19p13.3 | Lipid homeostasis | KO [96] | Logue et al. 2014 [48] |
APOE | Apolipoprotein E | 19q13.2 | Lipid catabolism | Klaver et al. 1998 [67] | |
CETP | Cholesteryl ester transfer protein | 16q21 | Lipid metabolism | transgenic [99] | Chen et al. 2010 [50] |
LIPC | Hepatic triglyceride lipase | 15q21.3 | Lipid metabolism | KO [100] | Chen et al. 2010 [50] |
MMP9 | Matrix metalloproteinase-9 | 20q13.12 | ECM breakdown/angiogenesis | KO [101] | Hussain et al. 2011 [70] |
PLTP | Phospholipid transfer protein | 20q13.12 | Lipid transfer to HDL | Fritsche et al. 2015 [24] | |
VTN | Vitronectin | 17q11 | Cell adhesion/complement pathway | No | Fritsche et al. 2015 [24] |