From: Practical issues concerning tear protein assays in dry eye
Class of tear protein | Potential clinical marker | Human tear levels show consistent dysregulation | Human tear levels linked to clinical signs/symptoms of dry eye | Change with treatment or severity of dry eye? | Biological function in dry eye pathology known? |
---|---|---|---|---|---|
Lacrimal protein | Lactoferrin | + [28] | ++ [29] | ||
Protease | MMP-9 | +++ [11] | +++ [33] | ||
Lacrimal protein | Lysozyme | + [43] | 0 | 0 | |
Mucins | MUC5AC | + [48] | 0 | ||
Lipid binding protein | Lipocalin | + [52] | ++ [52] | ||
Interleukines | IL-6 | + [58] | ++ [58] | ||
Chemokine | IL-8 | ++ [62] | 0 | ||
Keratinisation-related | S100A8/9 | 0 | |||
Epithelial health | EGF | + [69] | 0 | ++ [70] | |
Neurotrophic health | NGF |